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Reported side effects are generally mild, including bloating, gas, and digestive discomfort, particularly when first starting the supplement
Phase II neutralizes them by covalently attaching a conjugation group (glucuronic acid, glutathione, sulfate, acetyl, methyl, or amino acid) that increases polarity, reduces reactivity, and enables transport into bile or urine
With gastric sleeve, the treatment is the procedure itself
The WHO guideline also emphasized that obesity is a chronic, relapsing disease requiring long-term treatment, not a short-term intervention
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